| Date | May 2017 | Marks available | 2 | Reference code | 17M.3.HL.TZ2.12 |
| Level | Higher level | Paper | Paper 3 | Time zone | Time zone 2 |
| Command term | Outline | Question number | 12 | Adapted from | N/A |
Question
Outline one way in which genetic sequences can be used to indicate predisposition to a disease.
Outline the use of luminescent probes in the treatment of tumours.
Markscheme
a. genetic markers/specific sequences can be present in people with a disease OWTTE
b. presence «of markers/specific sequences» indicates risk/probability of onset of condition Allow vice versa.
c. technique to detect the presence of the sequence eg: PCR, electrophoresis, DNA sequencing, FISH, DNA databases, etc.
d. example of predisposition eg: BRCA sequence mutations indicating predisposition to breast cancer
a. transferrin/other protein taken up at higher rates by tumour cells
b. transferrin/other protein can be labelled with a luminescent dye
c. different tumour cell types can be distinguished/labelled in different colours
d. can be used to highlight tumours «during surgery» OWTTE
